What does “Error loading block database” mean?

It means your copy of the blockchain is corrupt and needs replacing.

Go into your XP data directory:

Windows: %APPDATA%\eXperiencePoints\
Linux: ~/.eXperiencePoints/
Mac OSX: $HOME/Library/Application Support/eXperiencePoints/

Delete the following folders:

blocks
chainstate
database
sporks
zerocoin

Download the latest bootstrap and extract it (see “How do I use the bootstrap/snapshot?” for details).

Restart the wallet and let it sync fully.